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Studies Found: 230

BRAIN - BRAIN INJURY

Hydrogen-Rich Saline Attenuated Subarachnoid Hemorrhage-Induced Early Brain Injury in Rats by ...

Year Published: 2015

Early brain injury (EBI), highlighted with inflammation and apoptosis, occurring within 72 h after subarachnoid hemorrhage (SAH), is associated with the prognosis of SAH. Recent studies have revealed that hydrogen-rich saline (HS) exerted multiple neuroprotective properties in many neurological diseases including SAH, involved to anti-oxidative and anti-apoptotic effect. We have previously ...
BRAIN - BRAIN INJURY

Protective effect of molecular hydrogen against white matter ischemic injury

Year Published: 2015

The central nervous system (CNS) white matter (WM) ischemia is an important clinical problem and may produce injury, in part, by reactive oxygen species (ROS)-induced mitochondrial dysfunction. Using the mouse optic nerve (MON) WM model, we tested whether hydrogen (H2) in drinking water reduced functional WM ischemic injury. Functional integrity of MON was determined by quantitatively monitoring ...
BRAIN - TRAUMATIC BRAIN INJURY

Changes of immuno-inflammatory responses by intraperitoneal injection of hydrogen after diffuse ...

Year Published: 2015

To explore the role of immuno-inflammatory reaction in diffuse axonal injury (DAI) and the therapeutic action of hydrogen in DAI model. Methods Totally 96 adult male SD rats were divided into 8 groups (n=12 in each): normal group, sham group, DAI groups (6h, 1d and 3d) and DAI with hydrogen treatment groups(6h, 1d and 3d). Rat DAI model was induced by an experimental facility developed to make the ...
BRAIN - ALZHEIMER'S DISEASE

Hydrogen-rich water attenuates amyloid β-induced cytotoxicity through upregulation of Sirt1-FoxO3a ...

Year Published: 2015

Amyloid β (Aβ) peptides are identified in cause of neurodegenerative diseases such as Alzheimer's disease (AD). Previous evidence suggests Aβ-induced neurotoxicity is linked to the stimulation of reactive oxygen species (ROS) production. The accumulation of Aβ-induced ROS leads to increased mitochondrial dysfunction and triggers apoptotic cell death. This suggests antioxidant therapies may be ...
BRAIN - BRAIN INJURY

Hydrogen-rich water protects against ischemic brain injury in rats by regulating calcium buffering ...

Year Published: 2015

Hydrogen-rich water (HRW) has anti-oxidant activities, and it exerts neuroprotective effects during ischemia-reperfusion brain injury. Parvalbumin and hippocalcin are two calcium buffering proteins, which are involved in neuronal differentiation, maturation and apoptosis. The aim of this study was to investigate whether HRW could moderate parvalbumin and hippocalcin expression during ischemic ...
BRAIN - NEUROPATHIC PAIN

H2 Treatment Attenuated Pain Behavior and Cytokine Release Through the HO-1/CO Pathway in a Rat ...

Year Published: 2015

Neuropathic pain (NP) is characterized by persistent pain, tactile allodynia, or hyperalgesia. Peripheral nerve injury contributes to rapid progress of inflammatory response and simultaneously generates neuropathic pain. Hydrogen (H2) has anti-inflammation, anti-apoptosis, and anti-oxidative stress effects. Therefore, we hypothesized that H2 treatment could alleviate allodynic and hyperalgesic ...
BRAIN - MULTIPLE SCLEROSIS

Hydrogen-rich water improves neurological functional recovery in experimental autoimmune ...

Year Published: 2016

Multiple sclerosis (MS) is a chronic autoimmune demyelinating disease of the central nervous system (CNS). The high costs, inconvenient administration, and side effects of current Food and Drug Administration (FDA)-approved drugs often lead to poor adherence to the long-term treatment of MS. Molecular hydrogen (H2) has been reported to exhibit anti-oxidant, anti-apoptotic, anti-inflammatory, ...
BRAIN - STRESS RESILIENCE

Effects of hydrogen-rich water on depressive-like behavior in mice

Year Published: 2016

Emerging evidence suggests that neuroinflammation and oxidative stress may be major contributors to major depressive disorder (MDD). Patients or animal models of depression show significant increase of proinflammatory cytokine interleukin-1β (IL-1β) and oxidative stress biomarkers in the periphery or central nervous system (CNS). Recent studies show that hydrogen selectively reduces cytotoxic ...
BRAIN - PARKINSON'S DISEASE

A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: ...

Year Published: 2016

Background: Our previous randomized double-blind study showed that drinking hydrogen (H2) water for 48 weeks significantly improved the total Unified Parkinson's Disease Rating Scale (UPDRS) score of Parkinson's disease (PD) patients treated with levodopa. We aim to confirm this result using a randomized double-blind placebo-controlled multi-center trial. Methods: Changes in the total UPDRS scores ...
BRAIN - BRAIN INJURY

Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy

Year Published: 2016

This study retrospectively analyzed the efficacy of hydrogen water in the treatment of neonatal hypoxic-ischemic encephalopathy (HIE) and its effect on serum neuron-specific enolase (NSE), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) levels. Forty newborns with HIE who received treatment from April 2014 to April 2015 were divided into a conventional care group and a hydrogen water ...
BRAIN - BRAIN INJURY

The protective effects of hydrogen on HO-1 expression in the brainafter focal cerebral ischemia ...

Year Published: 2016

Background/aim: The aim of this study was to investigate whether a hydrogen administration can produce neuroprotective effects after brain ischemia reperfusion in rats. Materials and methods: A brain ischemia reperfusion injury was induced by a 2-h left middle cerebral artery occlusion (MCAO) using an intraluminal filament, followed by 46 h of reperfusion. A hydrogen-rich saline (1 mL/kg body ...
BRAIN - CARDIOPULMONARY RESUSCITATION (CPR)

Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological ...

Year Published: 2016

Background: Non-shockable rhythms represent an increasing proportion of reported cases of out-of-hospital cardiac arrest but with an associated poor prognosis. In the present study, we investigated the effects of hydrogen inhalation on cardiac and neurological function after cardiopulmonary resuscitation and compared the therapeutic benefit with hypothermia in an asphyxial rat model of cardiac ...
BRAIN - BRAIN INJURY

Hydrogen does not Exert Neuroprotective Effects or Improve Functional Outcomes in Rats After ...

Year Published: 2016

Aim: Increasing evidence suggests that reactive oxygen species damage the blood-brain barrier and increase brain edema after intracerebral hemorrhage (ICH). Recently, strong clinical and experimental evidence has shown that hydrogen has potent protective cellular effects in various diseases. However, the effect of hydrogen on ICH remains unclear. The present study investigates whether hydrogen has ...
BRAIN - BRAIN INJURY

Molecular hydrogen affords neuroprotection in a translational piglet model of hypoxic-ischemic ...

Year Published: 2016

Hypoxic-ischemic encephalopathy (HIE) is the major consequence of perinatal asphyxia (PA) in term neonates. Although the newborn piglet is an accepted large animal PA/HIE model, there is no consensus on PA-induction methodology to produce clinically relevant HIE. We aimed to create and to characterize a novel PA model faithfully reproducing all features of asphyxiation including severe hypercapnia ...
BRAIN - STROKE

Neuroprotective Effect of Hydrogen-Rich Saline in Global Cerebral Ischemia/Reperfusion Rats: ...

Year Published: 2016

Recently, it has been suggested that molecular hydrogen (H2) can selectively reduce the levels of hydroxyl radicals (.OH), and ameliorate oxidative and inflammatory injuries to organs in global cerebral ischemia reperfusion models. Global cerebral ischemia/reperfusion (I/R) can induce a sudden activation of inflammatory cytokines and later influence the systemic immunoreactivity which may ...
BRAIN - ALZHEIMER'S DISEASE

Electrolyzed-reduced water mitigates amyloid beta toxicity via DAF-16 in C. elegans

Year Published: 2016

Alzheimer’s disease is an age-related neurodegenerative disease. Extracellular aggregation of amyloid beta is a well-known hallmark of Alzheimer’s disease and believed to be critical for the development of Alzheimer’s disease. Lots of efforts have been put on finding an intervention alleviating amyloid beta toxicity. Electrolyzed-reduced water is generated near cathode by electrolysis of ...
BRAIN - TRAUMATIC BRAIN INJURY

Effects of hydrogen-rich water on the expression of aquaporin 1 in the cerebral cortex of rat with ...

Year Published: 2016

Objective: To investigate the effect of hydrogen-rich water on cerebral edema and aquaporin 1 (AQP1) expression in rats with traumatic brain injury (TBI). Methods: Ninety male Sprague-Dawley (SD) rats were randomly divided into sham operation group, TBI model group, hydrogen-rich water treatment group (H group),with 30 rats in each group. TBI model was reproduced by weight dropping method. The ...
BRAIN - STROKE

Inhalation of water electrolysis-derived hydrogen ameliorates cerebral ischemia–reperfusion injury ...

Year Published: 2016

Hydrogen is a kind of noble gas with the character to selectively neutralize reactive oxygen species. Former researches proved that low-concentration of hydrogen can be used to ameliorating cerebral ischemia/reperfusion injury. Hydrogen electrolyzed from water has a hydrogen concentration of 66.7%, which is much higher than that used in previous studies. And water electrolysis is a potential new ...
BRAIN - BRAIN INJURY

Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress ...

Year Published: 2016

Hydrogen as a new medical gas exerts organ-protective effects through regulating oxidative stress, inflammation and apoptosis. Multiple lines of evidence reveal the protective effects of hydrogen in various models of brain injury. However, the exact mechanism underlying this protective effect of hydrogen against hypoxic-ischemic brain damage (HIBD) is not fully understood. The present study was ...
BRAIN - PARKINSON'S DISEASE

Complexity of Stomach-Brain Interaction Induced by Molecular Hydrogen in Parkinson’s Disease ...

Year Published: 2017

Molecular hydrogen (H2), as a new medical gas, has protective effects in neurological disorders including Parkinson's disease (PD). In our previous report, the neuroprotective effect of drinking water with saturated H2 (H2 water) in PD mice might be due to stomach-brain interaction via release of gastric hormone, ghrelin. In the present study, we assessed the effect of H2-induced ghrelin more ...
BRAIN - SURGERY/TRANSPLANTATION

Hydrogen gas alleviates oxygen toxicity by reducing hydroxyl radical levels in PC12 cells

Year Published: 2017

Hyperbaric oxygen (HBO) therapy through breathing oxygen at the pressure of above 1 atmosphere absolute (ATA) is useful for varieties of clinical conditions, especially hypoxic-ischemic diseases. Because of generation of reactive oxygen species (ROS), breathing oxygen gas at high pressures can cause oxygen toxicity in the central nervous system, leading to multiple neurological dysfunction, which ...
BRAIN - SURGERY/TRANSPLANTATION

Molecular hydrogen inhalation attenuates postoperative cognitive impairment in rats

Year Published: 2017

Postoperative cognitive decline is a major clinical problem with high morbidity and mortality after surgery. Many studies have found that molecular hydrogen (H2) has significant neuroprotection against acute and chronic neurological injury by regulating inflammation and apoptosis. In this study, we hypothesized that H2 treatment could ameliorate the development of cognitive impairment following ...
BRAIN - ADDICTION

Hydrogen-rich saline attenuates anxiety-like behaviors in morphine-withdrawn mice

Year Published: 2017

Hydrogen therapy is a new medical approach for a wide range of diseases. The effects of hydrogen on central nervous system-related diseases have recently become increasingly appreciated, but little is known about whether hydrogen affects the morphine withdrawal process. This study aims to investigate the potential effects of hydrogen-rich saline (HRS) administration on naloxone-precipitated ...
BRAIN - SURGERY/TRANSPLANTATION

Effects of Hydrogen-Rich Saline on Hepatectomy-Induced Postoperative Cognitive Dysfunction in Old ...

Year Published: 2017

This study aims to investigate the protective effects and underlying mechanisms of hydrogen-rich saline on the cognitive functions of elder mice with partial hepatectomy-induced postoperative cognitive dysfunction (POCD). Ninety-six old male Kunming mice were randomly divided into 4 groups (n = 24 each): control group (group C), hydrogen-rich saline group (group H), POCD group (group P), and POCD ...
BRAIN - NEUROPROTECTION

Hydrogen gas attenuates sevoflurane neurotoxicity through inhibiting nuclear factor ...

Year Published: 2017

Anesthesia neurotoxicity in developing brain has gained increasing attention. However, knowledge regarding its mitigating strategies remains scant. Sevoflurane, a commonly used anesthetic, is responsible for learning and memory deficits in neonates. Molecular hydrogen is reported to be a potential neuroprotective agent because of its antioxidative and anti-inflammatory activities. This study aimed ...